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Multiple autoimmune conditions responding simultaneously to a single intervention is unusual in rheumatology, where treatment typically requires different medications targeting different pathways

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Specifically, the underlying mechanisms may include the following: (1) Advanced glycation end products (AGEs) exert their effects by binding to the receptors for advanced glycation end products (RAGEs), which upregulates the production of pro-inflammatory mediators, facilitates protein cross-linking, and ultimately exacerbates atrial structural remodeling (56)

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