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Differentially methylated positions and gene expression data were used to draw information concerning functional enriched pathways via annotation analyses that were integrated with metabolomic findings to reveal coordinated alterations in key bioenergetic and amino acid metabolic signaling [25, 26]

Metformin treatment mitigated albuminuria and renal histopathology, and decreased the expression of TGF1 and SMA in the kidneys of STZ-induced C57/BL6J diabetic mice (145)