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The biological mechanisms underlying these associations remain uncertain, as available human data are limited and largely speculative

Of note, however, in a 40 week Phase 3 study of overweight/obese individuals with type 2 diabetes, 36 mg of orforglipron taken orally once daily achieved reductions in HbA 1c of ~12 mmol/mol (1.07%) and in body weight of 5.9 kg (placebo subtracted) with an adverse event profile similar to that of the established GLP-1RA class [83]

Giugliano D, Maiorino MI, Bellastella G, Longo M, Chiodini P, Esposito K

Or worse, it drops a little, then