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This represents a pharmaceutical design strategy of creating selectivity through structural modification, providing therapeutic benefits while minimizing unwanted effects

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These effects could be particularly valuable in treating conditions such as inflammatory bowel disease, where mucosal healing is a critical therapeutic endpoint

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An increased risk of developing diabetes with EGRIFTA (HbA1c level 6.5%) relative to placebo was observed [intent-to-treat hazard odds ratio of 3.3 (CI 1.4, 9.6)]