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This work was supported by the National Key Research and Development Program of China (No.2024YFD1300701), the Guangxi open competition Technology Project, research and application of pig genome selection breeding technology (GuikeJB23023003)

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The TME refers to the microenvironment around the tumor and all it encompasses (Figure 2), from the blood vessels to stroma, cancer stem cells (CSCs), epithelial cells, fibroblasts, immune cells (including macrophages and T cells) and other factors including growth factors, cytokines, the extracellular matrix (ECM), cell-matrix interactions, pH and oxygen concentration (Yang and Gao, 2017

With reflux, stomach acid can inflame the throat, Dr