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When to contact a healthcare provider : Patients should seek medical advice if they experience: Severe or persistent abdominal pain, especially if radiating to the back (potential pancreatitis) Right upper quadrant pain, fever, or yellowing of skin/eyes (potential gallbladder disease) Inability to pass gas or stool for more than 3 days Vomiting that prevents adequate hydration Signs of dehydration (dark urine, dizziness, decreased urination) Blood in stool or black, tarry stools Unintentional weight loss exceeding expected therapeutic effects New or worsening symptoms after several weeks of stable treatment Patients experiencing persistent gastrointestinal symptoms should discuss with their provider whether adjusting the tirzepatide dose escalation schedule or temporarily holding at a lower dose might improve tolerability while maintaining therapeutic benefits

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Proteomic profiling indicates persistent stress-response and antioxidant upregulation at 6 months in PCS Compared with recovered individuals, 6-month PCS patients exhibited broad and sustained upregulation of cellular stress-response proteins, particularly chaperones and proteinquality control regulators ( Figure 6D )

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It's important to note that these findings primarily come from studies of people with normal to slightly elevated blood pressure