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Untreated vitamin B12 deficiency can lead to anemia or irreversible nerve damage

Despite rapid progress in this field, there remains a lack of systematic integration regarding how key metabolic axes, including arginine metabolism, tryptophan catabolism, and glutamine metabolism, coordinately or antagonistically drive macrophage functional reprogramming, as well as the conservation, heterogeneity, and translational significance of these changes across different autoimmune-related diseases

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Patients should be monitored closely for any signs of respiratory distress

Restraining Factors The market faces challenges including limited clinical standardization across treatment protocols, regulatory scrutiny regarding off-label cosmetic applications, high treatment costs, variability in treatment outcomes, shortage of qualified healthcare professionals, and concerns related to long-term efficacy and safety