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Therefore, regulating the phenotypic polarization of microglia, particularly promoting the transformation from pro-inflammatory M1-type microglia to anti-inflammatory M2 phenotype, represents a promising therapeutic strategy for normalizing the brain neuroinflammatory environment [52]

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[DOI] [PubMed] [Google Scholar] 38.Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, et al

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Glutathione S-transferases (GSTs) catalyze the conjugation of GSH to a broad range of electrophilic compounds, including endogenous signaling molecules, reactive aldehydes such as 4-hydroxynonenal (4-HNE), and heavy metals 13,14

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