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As of mid-2026, neither is FDA- or EMA-approved

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The cells are suspended in large amounts of mucoid material that stains positively with Alcian blue and colloidal iron stains and is depolymerized by prior treatment of the sections with hyaluronidase, although this is of little practical diagnostic value

Therefore, in order not to repeat the information given in several review papers, we refer the reader to some of those papers [80,81]

Typical in vitro models include fibroblast scratch assays, endothelial tube formation assays, and macrophage polarisation studies.