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This unintended muscle catabolism can: Slower Metabolic Rate Decreased Strength and Functional Ability Increased Risk of Bone Density Loss Bottom line: Preserving muscle is essential to harnessing the full health benefits of GLP-1 therapy and avoiding frailty or metabolic rebound

Among the 298 patients whose tumors were PD-L1-negative, those treated with pembrolizumab remained cancer free for a median of 17.3 months, compared with nine months for the observation group

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Biochemistry 39 , 1300513011 (2000)