Decreased sympathetic nerve firing leads to arterial vasodilation, resulting in reduced total peripheral resistance (TPR), and venodilation, resulting in decreased venous return (preload)
Part of the answer is because NAD + has non-redox uses
One step towards resolution would be to combine the cerebrospinal fluid specimens for standardized targeted mass spectrometry analysis followed by multivariate analysis of age, gender, exercise status and levels of severity such as poor quality of life, pain, fatigue and interoceptive complaints
Di Paola R, Modafferi S, Siracusa R, Cordaro M, D'Amico R, Ontario ML, Interdonato L, Salinaro AT, Fusco R, Impellizzeri D, Calabrese V, Cuzzocrea S
Bacterial biofilms: from the natural environment to infectious diseases