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Statistical analyses were performed using the statistical tools implemented in GraphPad Prism10 (v10.0.3), and after testing of data for normal distribution using the KolmogorovSmirnov test, DAgostino and Pearson test, AndersonDarling test or ShapiroWilk test implemented in GraphPad Prism (v10.0.3)

Importantly, however, many historically transformative drugs were approved without a complete mechanistic understanding or full translational validation prior to human testing

Participants did not have type 2 diabetes

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