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DSIP was discovered decades ago and initially attracted substantial scientific interest, yet large contemporary clinical programs did not emerge

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included subjects in the full schizophrenia spectrum: at high risk for psychosis (HR), patients with first-episode psychosis (FEP), or patients with established schizophrenia (medicated and unmedicated), as well as treatment-resistant schizophrenia (TRS) and HV [41]

Participants randomized to valerian took 200 mg of the extract, standardized to contain 2% total valerenic acid, daily