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In addition to direct effects on ion channels, neurotransmitters may bind to G-protein coupled receptors, thereby eliciting cell-signaling effects that could result in metabolic changes (e.g., alterations in activity of various enzymes) within a postsynaptic cell (14)

Some researchers believe that this happens because the therapies fail to eradicate a small proportion of cells that drive tumour growth known as cancer stem cells

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The response is to remove the catheter immediately, culture the drainage, and start antibiotic therapy while watching for signs of sepsis

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