Alternatively, the elution separating the target GLP-1 moiety from the form comprising an extra arginine residue employing organic modifier could be performed below pH 12.0 simply by a salt component (gradient or isocratically) at eluting conditions
Here we aimed to determine whether sequence differences at the ligand C-termini of clinically approved GLP-1RAs exendin-4 and lixisenatide lead to similar phenomena
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Am J Physiol, 1995;269: E239-E46