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Due to the fact that ACTL6A did not regulate NRF2, we could reach the conclusion that ACTL6A functions in conjunction with NRF2 to regulate GCLC expression at the transcriptional level

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As Kynurenine pathway is positively correlated with BMI, there is still an interaction between the pathophysiological mechanism of PCOS and abnormal tryptophan metabolism after excluding the influence of obesity