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FDA-approved weight management medications beyond GLP-1 agonists include: Phentermine-topiramate (Qsymia): Combination sympathomimetic and anticonvulsant showing 8-10% weight loss in clinical trials

It can be enjoyed on its own or used in mixed drinks in moderation

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Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

One of the ongoing debates about this entire class of medications is whether the effects are mediated solely by weight loss and mitigation of the inflammatory consequences of energy toxicity (read: too many calories) versus other biological effects of these medications