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Several hypothetical explanations exist for why some patients report skin breakouts or changes while taking tirzepatide, even in the absence of a direct pharmacologic mechanism

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It was developed as a selective alternative to earlier GHRPs such as GHRP-2 and GHRP-6, and has been widely studied for its relatively clean receptor-selectivity profile stimulating GH release with comparatively little impact on cortisol and prolactin levels in preclinical models