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Her grandmother died of complications from RA, and in the last few months of her life, it was Smith who served as her caregiver, administering doses of methotrexate to treat her pain and inflammation

The gene therapy is specifically approved for those patients who currently use factor IX (FIX) prophylaxis therapy, or have current or historical life-threatening hemorrhage, or repeated, serious spontaneous bleeding episodes and do not have neutralizing antibodies to the adeno-associated virus serotype Rh74var (AAVRh74var) capsid