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Furthermore, in aged mice treated with lipopolysaccharide to increase BBB permeability, melatonin-activated AMP-activated protein kinase in endothelial cells of the BBB [197], a kinase essential for maintaining BBB integrity [198]

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Describing the said invention or discovery, clearly, truly and fully, and thereupon granting to such petitioner or petitioners, his, her or their heirs, administrators or assigns for any term not exceeding fourteen years, the sole and exclusive right and liberty of making, constructing, using and vending to others to be used, the said invention or discovery [] The actual term, therefore, was settled individually for each patent