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10.1016/j.bbr.2017.05.013 214

Patients with certain genetic profiles may need lower starting doses to avoid early fatigue, while others tolerate faster escalation without side effects

Moreover, improvements in drug formulations (such as those which do not require reconstitution or dose titration) and injection devices with hidden and pre-attached needles, which together serve to reduce treatment complexity, may lead to a more positive injection experience for patients (Table 3) [68]