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IV glutathione offers 90-100% bioavailability but may cause serious adverse events including anaphylaxis and hepatotoxicity

Statements Author contributions QW and ZC designed the study, searched the literature, and drafted the manuscript

Most gastrointestinal side effects improve significantly after the body adjusts to the medication

Small molecules designed to modulate MCT transporters or site-specific lactylation marks could offer a more nuanced approach than global metabolic inhibition

Key implementation steps for researchers include: establishing proper laboratory infrastructure, developing comprehensive safety protocols, implementing quality control measures, and maintaining detailed documentation throughout the research process