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Causes of Melasma: Hormonal fluctuations (pregnancy, birth control pills, hormone therapy) UV radiation exposure Genetic predisposition Heat and infrared light Appearance of Melasma: Symmetrical patches on the cheeks, forehead, nose bridge, or upper lip Larger, diffused patches rather than sharp dark spots Worsens with sun exposure What is Post-Inflammatory Hyperpigmentation (PIH)

Modulates expression of over 4,000 genes involved in tissue remodeling, including upregulation of collagen, elastin, and glycosaminoglycan synthesis

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