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The sustained nature of the GLP-1 increase suggests the possibility that metformin may in part provide cardio-metabolic benefit, even in a non-diabetic population and beyond reducing the risk of developing T2DM, by increasing exposure of treated individuals to GLP-1 in the longer term

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Peak weight loss velocity typically occurs between months two and six, with results continuing more gradually through month 12 and beyond as long as you remain on the medication