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In rats, both acute (4-h) and subchronic (7-day) cagrilintide treatment increased predicted Fos regulon activity in Glu4.2 Calcr/Ramp3 cells (adjusted P value ( P adj ) = 0.037 and P adj = 0.026, respectively

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Methods The proteins encoded by the methylenetetrahydrofolate reductase ( MTHFR ) and glutathione S-transferase omega-1 ( GSTO-1 ) genes are, through oxidative mechanisms, key participants in the cerebral response to ischemia

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