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However, prolonged exposure to GLP-1RAs can lead to tachyphylaxis, reducing their effect on gastric emptying over time

PlexusDx offers tirzepatide injection at $289/mo month-to-month, or from $249/mo on the 6-month plan and GLP-Squared Injection (a compounded dual compound combining semaglutide and tirzepatide) at $289/mo month-to-month, or from $249/mo on the 6-month plan

Sector allocation Sector allocation (as of 6/30/2026) Sector weighting is based on a representative account within the Allspring Global Investments composite and may have changed since the date specified

Accordingly, PD studies showed no difference in clinically relevant endpoints, further supporting the similar bioavailability of drugs when simultaneously prescribed with a GLP1RA