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They are involved in peripheral and central pathways mediating the regulation of food intake and play a role in pancreatic hormone secretion, glucose homeostasis, lipid metabolism, gastrointestinal motility, satiety and appetite, immune function and provide an improved metabolic efficacy in the management of T2D [3].The success of recent cardiovascular outcome trials of GLP-1 receptor agonists has raised interest in bioengineered unimolecular dual or triple gut hormone agonists, which represent attractive targets for managing obesity and metabolic disorders [4]

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