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In doing so, the permeation enhancing capabilities would be retained, as the organic moiety is responsible for interacting with the epithelial membrane, while the cation would affect the physical form of the salt, leading to a liquid state which would enable high concentrations of PE per dosage unit

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And I think that largely explains why the pharmacologic industry has failed

However, its important to be aware of possible reactions, 3 including: Common side effects : Nausea, vomiting, diarrhea, constipation, stomach pain Less common but serious risks : Severe gastrointestinal reaction, pancreatitis, acute kidney injury, hypoglycemia (especially if taken with insulin), visions changes (i.e., decreased/blurred vision), mental mood changes (i.e., depression, thoughts of suicide)