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Because of these factors, many early studies suggested that oral supplementation did very little to raise systemic levels

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Realistic expectations include progressive weight loss over a 12-20 week initial period, with the most significant changes becoming apparent after dose escalation is complete

Since vitamin C deficiency slows the rate of collagen formation, it causes wounds to heal more slowly ( Research has shown that people with chronic, non-healing leg ulcers are significantly more likely to be deficient in vitamin C than those without chronic leg ulcers ( In severe cases of vitamin C deficiency, old wounds may even reopen, increasing the risk of infection ( Slow wound healing is one of the more advanced signs of deficiency and typically not seen until someone has been deficient for many months ( Summary Vitamin C deficiency interferes with tissue formation, causing wounds to heal more slowly

H.OnodaN.IshikawaT.OgisawaK.TakenakaC.YanoY.et al (2002)