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Conclusions Our study demonstrates a detailed proteomic view of the stress response of H 2 O 2 treated chondrocytes, highlighting the significant changes in ER function, cytoskeletal remodeling, protein secretion, and immune responses

All statistical analyses were performed with SAS software, version 9.4 TS1M5 (SAS Institute)

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When tested as a once-daily injection in single and multiple doses varying up to 0.18 mg in healthy normal to overweight volunteers, gastrointestinal adverse events (nausea, diarrhoea, constipation, vomiting) were encountered, but the drug was described as well tolerated

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