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Within scientific research, this peptide has received considerable attention in recent years because of its potential role in repair processes, tissue regeneration and support of various biological systems

, & Holst, J

Studies on the effects of Ang A, a recently discovered novel human Ang-derived peptide, where only the N-terminal amino acid is different from Ang II, have also yielded conflicting results

These compounds are not approved by the FDA for use in humans or animals

Although these findings highlight integrin inhibitors as a viable class of ECM-targeted therapeutics, the majority of candidates remain at the preclinical or early clinical stage, and unresolved issues-including off-target toxicity, uncertainties in dose optimization, and limitations in delivery strategies pose substantial barriers to successful clinical translation (174)