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If constipation-predominant IBS worsens significantly or diarrhea-predominant IBS shifts to severe constipation, medication adjustment may be necessary

This means the body produces less natural steroid hormones, which can lead to fatigue, weakness, and other systemic symptoms

Phetntermine is a very effective weight loss drug but is associated with cardiovascular problems such as heart valve defects and pulmonary hypertension

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Code availability The pre-trained ensemble of deep multi-task neural-network models with weights used to draw the presented inferences, the code for the ensemble training, and the module for model-guided peptide sequence optimization together with all data used in this study are freely available for download from the online repository The repository contains IPython notebooks tutorials that demonstrate how to use the software