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Feb 12, 2026 Oral tirzepatide and injectable tirzepatide look like the same molecule on paper

doi: 10.3390/antiox8120628

This likely indicates inadequate absorption

Side-by-side comparison Factor Receptor targets Semaglutide GLP-1 only Tirzepatide GLP-1 + GIP Retatrutide GLP-1 + GIP + glucagon Liraglutide GLP-1 only Factor Half-life Semaglutide ~7 days Tirzepatide ~5 days Retatrutide ~6 days Liraglutide ~13 hours Factor Dosing frequency Semaglutide Once weekly Tirzepatide Once weekly Retatrutide Once weekly Liraglutide Once daily Factor Max studied dose Semaglutide 2.4 mg/week (SubQ)

Expert Opinion on Pharmacotherapy, 3(12), 1773-1781