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EBioMedicine 83, 104226

While the above evidence indicates that the mitochondrial apoptotic pathway promotes cell death, recent provocative evidence has shown that the intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in Caenorhabditis elegans by triggering a unique pattern of gene expression that modulates stress sensitivity and promotes survival (Yee et al., 2014)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Naraskai Y, Brent GA, You AS, et al

It finally gets uptake by the capillaries or the deeper tissue entering the systemic circulation