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Spending 6 to 8 weeks at each dose instead of 4 gives the body more time to adapt while maintaining the pharmacokinetic profile that the clinical trials validated

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Endocrinology 144 (5), 20552067

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With seven additional Phase 3 readouts expected in 2026, we believe retatrutide could become an important option for patients with significant weight loss needs and certain complications, including knee osteoarthritis." An investigational once-weekly triple hormone receptor agonist, retatrutide is a single molecule that activates the body's receptors for GIP, GLP-1, and glucagon

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