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In addition, pre-clinical studies also demonstrated that adverse changes in blood lipids (e.g., increase in TG, LDL levels, and decrease in HDL) and the development of IR were observed in male mice with castration (33)

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As the newest addition to incretin-based drugs, tirzepatide harbors the potential to counteract most of the pathogenetic mechanisms underpinning CKD in T2D displaying unprecedented features in terms of glucose and weight lowering, accompanied by promotion of insulin sensitivity, control of SBP, dyslipidemia, and biomarkers of inflammation and endothelial dysfunction