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If the preclinical data translate to the clinic, amylin has a good chance to supplant GLP-1 for the overweight to moderate obesity population March 7, 2025 8:46 PM UTC Incretin-based therapies have dominated the weight-loss Olympics, with companies chasing higher percentage losses like athletes chasing record-breaking scores

Starting at 2 mg instead of 4 mg significantly reduced early GI symptoms

But because these effects are dose-dependent, clinical trial data has consistently shown that the frequency and severity of GI side effects are significantly higher at the maximum therapeutic doses compared to the lower, initial titration doses

"Multi-disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network"

Additionally, the risk profiles are similar across brands