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Certain individuals may be at higher risk of experiencing gout whilst taking Wegovy, particularly those with pre-existing risk factors

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Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity

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Alongside prior preclinical work utilizing H4R blockers in UC models, 26, 27, 37 our work in human UC samples and experimental mouse models lends promise towards considering H4R blockers as a therapeutic option for UC in patients who are not severely immunocompromised as well as a useful adjunct therapy to be used alongside current therapies targeting the adaptive immune system