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A new model to study compensatory mechanisms in MPTP-treated monkeys exhibiting recovery
Oncogene , 2013, 32(15): 1971-1977
Particularly in groups receiving 600 and 900 mg/kg, erythrocyte immunoadhesive function was notably compromised, as demonstrated by a significant decrease in erythrocyte C3b receptor rosette rate (E-C3bRR) and an increase in erythrocyte immune complex rosette rate (E-ICRR) ( 5 Erythrocytes in pathogen recognition and responses Erythrocytes play a crucial role in pathogen recognition and immune responses
Intranasal administration can provide a direct nose-to-brain pathway via olfactory and trigeminal nerve routes, thereby reducing first-pass systemic degradation and potentially enhancing CNS exposure
and Ratkiewicz A
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