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Furthermore, DPP-IV inhibition prevented inflammation and mediated neuroprotective effect in two major complications of diabetes mellitus, namely ischemic stroke and retina damage

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Also in the rat brain, pre-treatment injection of trimetazidine (25 mg/kg/day for 7 days) prevented oxidative changes measured by SOD, catalase and malondialdehyde in a model of a sporadic type of Alzheimers disease [182]