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Differences between the groups during the OGTT were determined using two-way ANOVA, differences at fasting between multiple groups were analyzed using one-way ANOVA, both followed by Tukeys post hoc test, when the data followed the Gaussian distribution

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These data revealed that distinctions in peptide N-terminal interactions and dynamics with the GLP-1R transmembrane domain are reciprocally associated with differences in the allosteric coupling to G proteins

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