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However, these clinical trials have a short period and a small number of participants, and more in-depth clinical studies are needed before approval

(4) Compared with spontaneously formed cancer tissues in humans, cancer tissues in animal models lack the ability to reproduce the characteristics of human malignant tumors, which may lead to differences between the therapeutic effects observed in preclinical studies and clinical efficacy

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doi: 10.1016/j.molmed.2021.06.002 14 MuellerCLinJCSheriffSMaudsleyAAYoungerJW