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Original abstract content 2024 Association for Research in Vision and Ophthalmology.

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This review focuses on six commonly abused drugs (Table 1), classified based on their pharmacological and neurotoxic profiles: Psychostimulants: Methamphetamine (METH), cocaine and synthetic cathinones (bath salts) primarily act on monoaminergic systems, leading to disruptions in dopamine, serotonin, and norepinephrine signaling ( 2 O predominantly affect glutamatergic transmission by antagonizing NMDA receptors (NMDARs), causing excitotoxicity, mitochondrial dysfunction, and neuronal apoptosis

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