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Measurement of GSH/GSSG ratio, ROS, mitochondrial ROS, and mitochondrial membrane potential The ratio of reduced GSH to oxidized glutathione (GSSG) was measured by the GSH/GSSH assay kit (Abcam, ab205811) with the fluorescence (Ex/Em: 490/520 nm) recorded, following the manufacturers instructions

Intranasal GSH (Phase IIb): Randomized, double-blind, placebo-controlled study (n=45) tested intranasal reduced GSH 100 or 200 mg three times daily for 12 weeks

Ikeno M, Hibi H, Kinoshita K, Hattori H, Ueda M

BIOBERX LIPOSOMAL REDUCED L-GLUTATHIONE + VITAMIN C (as SODIUM L-ASCORBATE)

The latest draft MOU was published in 2020, but it was subsequently blocked by a federal court