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Gradual increase: Doses are slowly increased every 4 weeks or as tolerated

It inhibits the production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-12), modulates the polarization of macrophages towards the M2 (anti-inflammatory) phenotype, and stimulates collagen production in models of pulmonary and cutaneous fibrosis

Targeted metabolomics analysis revealed that GGCT knockdown significantly reduced the abundance of TCA cycle intermediates, while GGCT overexpression substantially increased their levels

This broad receptor activity makes it uniquely valuable as a pharmacological probe for studying the full melanocortin system in preclinical research, while also contributing to its broader side-effect profile

Avoid injecting right before important events or busy workdays, especially during dose escalation weeks when side effects are stronger