86 Fracture risk A large French cohort study involving 14 253 VSG patients reported an overall major osteoporotic fracture incidence of 1.70 per 1 000 person-years, with specific rates for distal forearm/wrist (0.82), proximal humerus (0.37), clinical vertebral (0.29), and hip fractures (0.22)
Studies have shown that GLP-1R agonists not only promote insulin secretion and exert glucose-lowering effects but also effectively delay gastric emptying, reduce intestinal motility, activate neural pathways in the hypothalamus and appetite regulation areas, resulting in decreased appetite and reduced food intake, thus treating obesity
Beginning in midlife, gradual loss of muscle and bone density becomes more common
Studies show insulin resistance prevalence decreased from 80.4% to 50%, irregular menstrual cycles decreased from 85.7% to 32.1%, and ovarian cyst prevalence dropped from 89.3% to 41%
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