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The indels result in a FGF5 protein frameshift or deletion of AA (Fig

This dual action stimulating collagen production while inhibiting breakdown is mechanistically distinct from retinoids, which primarily increase turnover without equivalent MMP inhibition

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Established CSF markers of neurodegeneration, including neurofilament light chain (NfL), t-tau, and AD-related amyloid/tau signaturesparticularly reduced A42 and composite ratios such as p-tau/A42 or A42/40have been associated with shunt outcome, but with limited and inconsistent predictive accuracy 3438

DOI Kang YA, Choi HR, Na JI, et al