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If age restrictions are too narrow or even minor medical conditions exclude individuals from trial participation, the pool of healthy volunteer candidates becomes even smaller

Tirzepatide acts on two pathways (GLP1 and GIP), while semaglutide targets GLP1

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The initial interpretation of these data was that they represented support for the presence of an NADPH-oxidase in spermatozoa that could be responsible for the high rates of NAD(P)H-induced, lucigenin-dependent chemiluminescence recorded in defective sperm populations [37]