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From a chromatographic theory perspective, SPPs improve performance by optimizing the A-term and C-term of the Van Deemter equation Reduced Eddy diffusion (A-Term): The uniform particle size distribution and packing density of core-shell columns reduce the multipath dispersion of analyte molecules as they travel through the bed

Senescent cells overexpress FOXO4, which sequesters p53 to prevent apoptosis in so-called zombie cells