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B.Brito-MoreiraJ.HouzelJ.-C.DeckerH.et al (2012)

Imcivree (setmelanotide) is specifically approved for individuals with certain rare genetic disorders such as POMC, PCSK1, or LEPR deficiencies, which affect the melanocortin-4 receptor pathway and lead to obesity

We predicted that disrupting its function would interfere with colonization and disrupt embryonic development, which does not proceed normally in the absence of Buchnera 7

Metabolomic analysis We used Biocrates AbsoluteIDQ p180 kit to analyze cardiac metabolites from female mice [Young ( n = 7), Old Con ( n = 8), and Old mAb ( n = 7)] with UPLC-MS/MS Xevo TQ, Waters, Pittsburgh, PA, USA) in the Einstein Stable Isotope and Metabolomics Core, according to the manufacturers instructions (BIOCRATES Life Sciences AG, Innsbruck, Austria)

Injections are typically self-administered once weekly